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I have adjusted and refined my setup many times over the past five years. I've bought, sold, re-bought, and rearranged countless modules and have finally (mostly) settled on what works for me. The general idea is aligned with the signal flow of a traditional fixed-architecture synth. After so much experimentation, I know how I usually use each module and I have arranged them to have the shortest cable runs possible. I like to constantly tweak knobs, so keeping cables as short and out of the way as possible is important for me. I try to have my signal flow going from left to right and top to bottom so I can avoid too many criss-crossing cables, which is visually important for me so I can remember where everything is going. I'm getting too old to remember how I've routed everything otherwise. Haha
Good luck and have fun!