You will be able to make some harsh noise with the Shard and Basimilus Iteritas Alter. The Malekko Varigate 4+ could be a consideration for you instead of the Mimetic Digitalis for a pitch and gate sequencer. Maybe look into that?
I haven't tried to feed a line input (for samples/external gear) into my Shard yet, but it destroys every other source I have put through it. A distortion would probably be a good addition, or a small guitar pedal i/o if you have some gnarly distortion/reverb/delay pedals that you want to incorporate.
I'm thinking in terms of Merzbow, MSBR, Vomir and that kind of stuff if that's the direction you are hoping to go.