You're thinking in terms of "main sequencer." That's fairly okay.
Where sequencing gets juicy (in my opinion) is combining different types of sequencers to perform different roles. I often combine stand alone trigger/gate sequencers with stand alone pitch sequencers to create something complicated. The sequencer might control an aspect other than pitch and the main volume VCA. It will run in tandem with my "main" sequencer using resets triggered from the main sequencer.
For example, I might have a Noise Engineering Mimetic Digitalis modifying my filter's resonance with a Temps Utile running a Euclidean pattern that triggers the Mimetic and another Euclidean firing off an envelope controlling the FM of the filter cutoff. Both Temps and Mimetic are reset by the main sequencer (usually a 1010 Music Toolbox). The main sequencer is still controlling the oscillator's pitch and the main VCA via another envelope.
You can substitute many different modules but the point is to get out of the idea that one sequencer of one type is going to get you interesting results. It's always good to have other sequencers in your set-up as they can really add some polish or interesting modulation to whatever you have going.