The way I organize things for workflow:
Audio moves left to right, and then eventually cascade top-down through/down to effects.
Sound sources/ oscillators --> filters --> vcas.
I also do tend to arrange adjacent horizontal rows as 'voices'.
Bottom row would be clock sources and sequencers (things that require hands-on input and adjustment). Modulation sources (Maths etc.) would be in the bottom two rows. I like Pam's in the bottom left corner.
Effects (Starlab etc) to the right, mostly bottom right. In my cases, clock enters bottom left, sound exits bottom right.
The reason I arrange things this way is so I can visualize the signal flow a little better. It also tends to shorten some of the patch cable lengths. Just the way I do it...