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Yes, the Mackie VLZs will handle synth level appropriately. Just back the trims way down, and there you go. I have an original 1202 that I've had for over 25 years, used it for literally everything imaginable, and it takes loads of signal level abuse and keeps on rolling. Even so, an output module with isolation can tease out some benefits in lowering noise floors, eliminating any potential of groundlooping, and the like. Since you're doing your FX on the Mackie's AUXes, there's another Happy Nerding output module that's just a straight stereo out...but with transformer isolation, and there is definitely some audio benefits to having a bit of 'iron' in your output path like that. Adds a touch of enharmonic nonlinearity that warms up sounds, as a rule, without really mangling them...unless (and this is a benefit, too) you push the transformers into saturation with some high levels, in which case you'll get a nice, warm, wooly saturated sound that you'll likely find some uses for.