You've got some real gems there... I've got a relatively large case as well (though not nearly this size), and I've found that arrangement helps tremendously. I move from left to right, sequencing -> modulation -> oscillators -> filters and VCA -> mixing and effects, with things that require more interaction or external connection toward the bottom and edges. Modular being what it is, there's a lot of flexibility toward what functions modules can serve, but finding an arrangement that orients you helps reduce the mental load of reorienting yourself over and over again.
The other thing I've found helpful is a change in mindset - just because you have a large case of modules doesn't mean they all have to occur in patches all the time. If you don't start from a melody or a musical idea, focus on exploring couple of modules or features, and build from there. That'll help you both master your system piece by piece and reduce the paralysis of having so many options to explore