Personally, for all of that plus the modules to sustain it, I would recommend a sequencer with more outputs and tracks, like a Hermod or Hermod+, Nerdseq+trigger expander, Per4mer, Eloquencer, etc. Plug a cheap MIDI keyboard in there for note entry in there and suddenly you've got a lot more going on for almost the same price.
You could get by with the Ground Control, I suppose, particularly if you find a good deal on it and have looked into the workflow to confirm you'll like it. The Pam's will be really important alongside that as well. I don't think Rene 2 can handle the job alone, though it may complement another sequencer very well. A Rene 1 can be found quite cheap to achieve something like this, or you can try the Hemispheres app that roughly emulates it.
Are you planning for this case to be at home or more of a live thing? Do the sounds need to be fairly melodic and gridded, or are you looking for things to be looser and more chaotic? You also have the option of getting MIDI to CV converters and just running this from your computer or other more traditional midi sequencer.
Overall, my personal opinion is that CV/Gate sequencing is better off having a free track or two that can be used to sequence weird stuff to see what happens, as opposed to having not quite enough when you want to do something full and alive with all those sound sources, samples, and triggered drums. If you decide less sequencing and more creative stretching of other modulation for musical results works better for you, that's fair, but it's worth considering - especially when a Ground Control is pretty expensive.