there are lots of theories on how to organise modules
clumps of functionality, clumped voices, voices left to right etc etc - you have to work it out for yourself - try a few different strategies and find the one that works best for you
but generally hands on control at the front tends to work best - joysticks, touchpads etc, sequencers - it really depends on the sequencer - and where the jack sockets are!
"some of the best base-level info to remember can be found in Jim's sigfile" @Lugia
Utility modules are the dull polish that makes the shiny modules actually shine!!!
sound sources < sound modifiers < modulation sources < utilities